Developing a cost-effectiveness model: HEOR virtual advisory board

HEOR virtual advisory board

Developing a cost-effectiveness model with global health technology assessment experts


A medical affairs team based in Europe wanted to hold a HEOR virtual advisory board to gather feedback on developing a cost-effectiveness model (CEM) for using a specific drug to treat patients with a type of cancer. The team’s primary objectives included:

  • Get advice on global CEM approaches for the drug as an adjuvant treatment for patients with the disease
  • Inform potential updates to proposed modeling approaches and methodologies
  • Obtain input from health technology assessment (HTA) experts on potential challenges that could arise when submitting the CEM to HTA authorities in different countries


The team contracted nine advisors from Canada, Australia, and several European countries to participate in an over-time virtual session on the Within3 insights management platform, allowing each participant to log in and contribute input whenever convenient. During the 12-day session, the advisors answered 18 questions, including an ice-breaker question to allow the advisors to get to know one another as the meeting began.

Questions in the session included What key subgroups, if any, would you expect are needed for the HTA submission dossier or CEM? and What are the key challenges you expect in an HTA submission for an adjuvant indication? During the session, the moderators were actively involved and asked follow-up questions to keep the conversation moving or probe for more information. Advisors also received periodic emails to remind them to answer new questions or respond to comments from their peers.


The medical affairs team was able to get the information they needed to develop the CEM. Outcomes attributed to the team’s choice of an asynchronous approach included:

  • 100% advisor participation despite busy schedules and different time zones
  • Ability to add a large number of session observers, who could follow the discussion and suggest areas of interest for follow-up to the moderators
  • Complete session transcripts viewable by question or by the individual advisor

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